Yanagisawa B & Resar LMS. Hitting the bull’s eye: Targeting HMGA1 in cancer stem cells.
Expert Review of Anticancer Therapy 2014; 14:23-30
1) HMGA FUNCTION
- Elucidating the molecular mechanisms that underlie HMGA function in normal development, including embryonic and adult stem cells
- Dissecting the molecular underpinnings of HMGA in cancer initiation and tumor progression
- Harnessing HMGA for regenerative medicine, including hematopoiesis, gut regeneration, & other tissues
2) TARGETING HMGA IN CANCER THERAPY
Huso T & Resar LMS. The HMGA1 molecular switch: Turning on cancer – Can we turn it off?
Expert Opinion On Therapeutic Targets 2014; 18:541-53.
- Developing strategies to block HMGA function in tumor initiation & progression
- Identifying approaches to target pathways that induce HMGA1
- Developing strategies to block pathways downstream of HMGA1